11/23/2023 0 Comments MyelopathicThe pathophysiology of DCM involves static and dynamic factors that lead to chronic spinal cord compression and resultant ischaemia, inflammation and apoptosis of neurons and oligodendrocytes.ĭiagnosis of DCM requires a careful history and physical examination to identify signs and symptoms of myelopathy and to rule out alternative diagnoses clinical findings should be correlated with MRI findings. With this Review, we aim to equip physicians across broad disciplines with the knowledge necessary to make a timely diagnosis of DCM, recognize the clinical features that influence management and identify when urgent surgical intervention is warranted.ĭegenerative cervical myelopathy (DCM) develops when age-related osteoarthritic or genetically based changes to the spinal column cause progressive compression of the cervical spinal cord, resulting in functional impairment.ĭCM is the most common cause of spinal cord impairment, and the resultant burden of disability on our society is expected to grow owing to the ageing global population. Here, we provide a comprehensive, evidence-based review of DCM, including its definition, epidemiology, pathophysiology, clinical presentation, diagnosis and differential diagnosis, and non-operative and operative management. Next-generation quantitative microstructural MRI and neurophysiological recordings promise to enable quantification of spinal cord tissue damage and help predict clinical outcomes. Surgical decompression is recommended for moderate and severe DCM the best strategy for mild myelopathy remains unclear. Over the past 10 years, advances in basic science and in translational and clinical research have improved our understanding of the pathophysiology of DCM and helped delineate evidence-based practices for diagnosis and treatment. Expeditious diagnosis and treatment of DCM are needed to avoid permanent disability. Owing to the ageing population, rates of DCM are increasing. These pathologies narrow the spinal canal, leading to chronic spinal cord compression and disability. DCM encompasses various acquired (age-related) and congenital pathologies related to degeneration of the cervical spinal column, including hypertrophy and/or calcification of the ligaments, intervertebral discs and osseous tissues. Degenerative cervical myelopathy (DCM) is the leading cause of spinal cord dysfunction in adults worldwide.
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